Microneedle-based two-step transdermal delivery of Langerhans cell-targeting immunoliposomes induces a Th1-biased immune response.

Novel Coronavirus is affecting human's life globally and vaccines are one of the most effective ways to combat the epidemic. Transcutaneous immunization based on microneedle (MN) has attracted much attention because of its painlessness, rapidity, high efficiency and good compliance. In this study, CD11c monoclonal antibody-immunoliposomes (OVA@CD11c-ILP) actively targeting to Langerhans cells (LCs) were successfully prepared and were delivered by the microchannels of skin produced by MN to induce an immune response in vivo. OVA@CD11c-ILP could be targeted to LCs by conjugating CD11c monoclonal antibody to the surface of the ILP. OVA@CD11c-ILP promoted the maturation of dendritic cells (DCs) and the uptake and endocytosis of antigen by LCs. Moreover, OVA@CD11c-ILP immunization can significantly inhibit tumor growth and prolong overall survival. Furthermore, a higher antibody's titer ratio of IgG1/IgG2a indicated that the immune response stimulated by this immunization method was Th1-biased and the liposomes showed Th1-type adjuvant effect. In conclusion, the combination delivery system of immunoliposomes and microneedle can significantly improve the efficiency of antigen presentation and effectively activate cellular immune responses in the body, which is expected to be a promising transdermal immune strategy.

Biosafety chemistry and biosafety materials: A new perspective to solve biosafety problems.

Coronavirus disease 2019 (COVID-19) has rapidly swept around the globe since its emergence near 2020. However, people have failed to fully understand its origin or mutation. Defined as an international biosafety incident, COVID-19 has again encouraged worldwide attention to reconsider the importance of biosafety due to the adverse impact on personal well-being and social stability. Most countries have already taken measures to advocate progress in biosafety-relevant research, aiming to prevent and solve biosafety problems with more advanced techniques and products. Herein, we propose a new concept of biosafety chemistry and reiterate the notion of biosafety materials, which refer to the interdisciplinary integration of biosafety and chemistry or materials. We attempt to illustrate the exquisite association that chemistry and materials science possess with biosafety -science, and we hope to provide a pragmatic perspective on approaches to utilize the knowledge of these two subjects to handle specific biosafety issues, such as detection and disinfection of pathogenic microorganisms, personal protective equipment, vaccine adjuvants and specific drugs, etc.. In addition, we hope to promote multidisciplinary cooperation to strengthen biosafety research and facilitate the development of biosafety products to defend national security in the future.

Biosafety materials: an emerging new research direction of materials science from the COVID-19 outbreak

The coronavirus disease 2019 (COVID-19) pandemic is a serious biosafety event that is causing a severe impact on the global society and economy. Thus, the importance of biosafety is once again being valued worldwide. Due to the outbreak of COVID-19, most national governments have been encouraged to speed up the development of biosafety, which places higher requirements on researchers in biosafety and relevant fields. Many problems have been exposed due to the outbreak of COVID-19, including unavailability of effective drugs and vaccines, difficulty in fast or real-time virus detection, insufficient protective equipment, and shortage of transportation equipment for infected patients. To a certain extent, these biosafety problems are partly due to the limited biosafety-related research in materials science. Currently, the tremendous research efforts in materials science around the world have provided a wide variety of materials with peculiar properties to solve biosafety problems. This review attempts to give a perspective on how the development of novel materials can help scientists tackle the challenges in biosafety. Considering the importance of materials science in the biosafety field, it is urgent for us to officially propose the brand new concept of "biosafety materials", which can be a future scientific discipline that utilizes materials science and theory simultaneously to produce materials, related products, and equipment to solve biosafety problems. Herein, we have aimed to draw worldwide attention on the new discipline of biosafety materials and the active cooperation between materials scientists and biosafety-related scientists to propel its development.